Lipoprotein-Associated Phospholipase A2 Loss-of-Function Variant and Risk of Vascular Diseases in 90,000 Chinese Adults
نویسندگان
چکیده
Lipoprotein-associated phospholipase A 2 (Lp-PLA 2) produces the proinflammatory mediators lysophos-phatidylcholine and oxidized free fatty acids through hydrolysis of oxidized phospholipids carried on low-density lipoproteins in atherosclerotic plaques. Although increased Lp-PLA 2 activity has been associated with higher risks of occlusive vascular diseases , recent phase III trials of the Lp-PLA 2 inhibitor darapladib, which reduces Lp-PLA 2 activity by w60%, failed to establish a protective role of darapladib for prevention of major vascular events in patients with stable coronary heart disease (CHD) or acute coronary syndrome (1,2).
منابع مشابه
A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults
BACKGROUND Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been implicated in development of atherosclerosis; however, recent randomized trials of Lp-PLA2 inhibition reported no beneficial effects on vascular diseases. In East Asians, a loss-of-function variant in the PLA2G7 gene can be used to assess the effects of genetically determined lower Lp-PLA2 METHODS: PLA2G7 V279F (rs76863441) w...
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عنوان ژورنال:
دوره 67 شماره
صفحات -
تاریخ انتشار 2016