Lipoprotein-Associated Phospholipase A2 Loss-of-Function Variant and Risk of Vascular Diseases in 90,000 Chinese Adults

نویسندگان

  • Iona Y. Millwood
  • Derrick A. Bennett
  • Robin G. Walters
  • Robert Clarke
  • Dawn Waterworth
  • Toby Johnson
  • Yiping Chen
  • Ling Yang
  • Yu Guo
  • Zheng Bian
  • Alex Hacker
  • Astrid Yeo
  • Sarah Parish
  • Michael R. Hill
  • Stephanie Chissoe
  • Richard Peto
  • Lon Cardon
  • Rory Collins
  • Liming Li
  • Zhengming Chen
چکیده

Lipoprotein-associated phospholipase A 2 (Lp-PLA 2) produces the proinflammatory mediators lysophos-phatidylcholine and oxidized free fatty acids through hydrolysis of oxidized phospholipids carried on low-density lipoproteins in atherosclerotic plaques. Although increased Lp-PLA 2 activity has been associated with higher risks of occlusive vascular diseases , recent phase III trials of the Lp-PLA 2 inhibitor darapladib, which reduces Lp-PLA 2 activity by w60%, failed to establish a protective role of darapladib for prevention of major vascular events in patients with stable coronary heart disease (CHD) or acute coronary syndrome (1,2).

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عنوان ژورنال:

دوره 67  شماره 

صفحات  -

تاریخ انتشار 2016